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The SCVC Blog

Cardiovascular care news and articles from our expert team

LDL Cholesterol Reduction: Absolute Beats Relative? It’s “And,” Not “Or”

Modern lipid management requires both substantial percentage LDL reduction and achieving low absolute LDL levels. Relative reduction reflects treatment intensity, while absolute LDL determines residual risk. Trials consistently show “lower is better.” Even with good percentage drops, patients may remain undertreated—making combined pharmacological and lifestyle strategies essential to reduce atherogenic exposure and cardiovascular risk.

Interpreting Liver Function Tests in MASLD: Why “Normal” May No Longer Mean Healthy

Traditional upper limits for ALT (often ≤55 U/L in UK labs) were derived decades ago, before the epidemic of obesity and steatosis. Current evidence suggests these ranges are too high — and that values above 30 U/L may already indicate liver injury in people with metabolic risk. The British Society of Gastroenterology (BSG) guidelines emphasise that a result within the “normal range” may not be reassuring if the patient is metabolically high-risk