Skip to main content

Providing independent clinical excellence since 2005

The SCVC Blog

Cardiovascular care news and articles from our expert team

Understanding Heart Attacks Beyond Coronary Artery Disease

Posted on Thursday April 4, 2024 in Heart Health

When we hear the term “heart attack,” it often conjures images of blocked arteries and emergency procedures to restore blood flow to the heart. Typically, this is due to coronary artery disease, where plaques build up in the coronary arteries, leading to conditions like myocardial infarction ( caused by coronary thrombosis). In cases of fatality, post-mortem terms like “atherosclerosis” or “acute myocardial infarction” highlight a direct link to this arterial blockage.

However, the medical understanding of a “heart attack” can sometimes diverge from the layperson’s perception. Many people interpret a heart attack as any acute, potentially fatal cardiac event, regardless of its cause. This discrepancy necessitates a deeper exploration of heart attack causes unrelated to coronary artery disease, particularly for understanding familial risks and discussing preventative measures like statins.

Uncommon Coronary artery Culprits of Heart Attacks, Not Linked to Atherosclerotic Heart Disease

1. Embolus from the Left Atrium

  • A clot from the left atrial appendage, especially in patients with atrial fibrillation, can travel to the coronary arteries, causing occlusion and symptoms indistinguishable from a classic heart attack.

2. Paradoxical Embolus via Patent Foramen Ovale (PFO) or Atrial Septal Defect (ASD)

  • Clots from veins can cross into the arterial system through a small hole in the heart Patent foramen ovale (PFO, present on 1 in 20 people) or Atrial septal defect (ASD), leading to coronary artery occlusion with symptoms similar to those of a heart attack caused by plaque rupture.

3. Spontaneous Coronary Artery Dissection (SCAD)

  • More common in women under 40, this uncommon condition involves a split or dissection in a coronary artery, causing occlusion and symptoms akin to a heart attack.

4. Coronary Spasm

  • Severe Prinzmetal angina or drug use (e.g., cocaine) can cause coronary artery smooth muscle spasm, resulting in chest pain and ECG changes similar to those seen in heart attacks from plaque rupture.

Other Conditions Mimicking Heart Attacks

1. Type 2 Myocardial Infarction

  • Situations causing a surge in cardiac enzymes, such as severe stress or illness, can mimic a heart attack without coronary artery blockage. Triggers include acute infection, sepsis, atrial arrhythmias with fast ventricular heart rates, falls in the elderly associated with a ‘long lie’ on the ground.

2. Structural and Valve Problems

  • Severe aortic stenosis or pulmonary hypertension can present with symptoms that resemble those of a heart attack and can go on to cause cardiac arrest.

3. Acute Pulmonary Embolism

  • A blockage from a large clot that has moved in the veins into the main pulmonary artery (saddle embolus) can lead to circulatory arrest, mirroring heart attack symptoms.

4. Takotsubo Cardiomyopathy

  • Takotsubo cardiomyopathy (TCM), often known as stress-induced cardiomyopathy or broken heart syndrome. This temporary heart condition is usually triggered by severe emotional or physical stress, leading to symptoms such as chest pain or shortness of breath that can closely resemble those of a heart attack.

5. Pericardial Tamponade

  • Fluid accumulation around the heart impedes its ability to fill properly, creating a scenario similar to a heart attack.

6. Acute Metabolic Crisis

  • Conditions like diabetic ketoacidosis can provoke cardiac symptoms that are mistaken for a heart attack.

7. Arrhythmias and Cardiomyopathies

  • Various inherited heart rhythm disorders (Brugada, long QT syndromes) and structural heart issues such as hypertrophic, hypertensive or dilated cardiomyopathies can lead to sudden cardiac events that mimic heart attacks.

Conclusion

Understanding that heart attacks can stem from a myriad of causes beyond coronary artery disease is crucial. This knowledge not only aids in accurate diagnosis and treatment but also in the preventive strategies and genetic counseling for families prone to non-atherosclerotic cardiac conditions. As we expand our perspective on what constitutes a heart attack, we pave the way for more personalized and effective cardiovascular care, ensuring that each patient receives the right attention based on the underlying cause of their cardiac event

More articles for you

Metabolic Health Assessment

Is is increasingly obvious that not everyone with raised coronary inflammation and elevated risk of heart attack simply has a raised LDL Cholesterol- in fact there appears to be a mixed bag of risk factors associated with high coronary artery inflammation, including raised LDL, raised LP (a), raised Homocysteine, hypertension and dysregulated glucose.   Our metabolic health assessment is therefore designed to offer a comprehensive dive into known contributory causes, the latest and most controversial of which is 'glucose dysregulation', the principle topic of this article.