Metabolic Health Archives | Page 2 of 5 | Surrey Cardiovascular Clinic

The SCVC Blog

Cardiovascular care news and articles from our expert team

Cholesterol, LDL, and what we learnt from PCSK9 mutations in familial hypercholesterolaemia

PCSK9 binds to LDL receptors and directs them to be destroyed within the cell, rather than allowing them to recycle to the surface. When too much PCSK9 is present, fewer LDL receptors remain available to clear LDL from the blood. The result is simple: LDL levels rise. When that happens, the liver compensates by making even more cholesterol internally. This is why around 90% of the cholesterol in your blood is made by your liver, not absorbed from your diet.

PCSK9, visceral fat, and the modern metabolic environment

Because cholesterol is a fat-like substance, it cannot dissolve or travel freely in blood, which is mostly water. To move around, it must be packaged into microscopic transport particles called lipoproteins. One of these, LDL (low-density lipoprotein), acts as the main delivery vehicle, carrying cholesterol from the liver to cells that need it for repair or hormone production. In small amounts, LDL cholesterol is therefore completely normal and necessary. The problem only begins when too much LDL remains circulating in the blood for too long.

Why HIIT Gets Rid of Visceral Fat — The Science Behind Anaerobic Exercise

HIIT interrupts this cycle by dramatically improving insulin sensitivity and glucose uptake in skeletal muscle — particularly in the large lower-limb muscles of the thighs and glutes. A single 20-minute session of HIIT can activate GLUT-4 transporters in muscle cells for up to 24–48 hours, drawing glucose out of the bloodstream and away from storage in the liver and visceral fat depots.

Intervention programmes: from self-toolkits to nurse-led escalation to GLP-1 support

At Surrey Cardiovascular Clinic, we move beyond detecting risk to delivering a tiered, personalised framework for metabolic and cardiovascular prevention. Using real-time tools like CGM, the DoctorShape app, imaging, and nurse-led coaching, we help patients reduce visceral adipose tissue, improve insulin sensitivity, and restore metabolic health through lifestyle-first, data-guided care.

Transforming metabolic health: cardiometabolic services at Surrey Cardiovascular Clinic

At Surrey Cardiovascular Clinic, we focus on preventing heart disease by tackling its metabolic roots early. Using advanced imaging, metabolic phenotyping, CGM, and tailored lifestyle or pharmacological interventions, we help patients reduce visceral adipose tissue (VAT), improve insulin sensitivity, and shift from risk to resilience through precision, feedback-driven cardiometabolic care.

UK Cholesterol, Apo B, LDL-C Targets

Small dense LDL (sdLDL) particles are the most atherogenic type of LDL. They are smaller and heavier, stay in the bloodstream longer and more likely to oxidise and enter artery walls. High sdLDL is typical of metabolic syndrome, diabetes, and high triglyceride states linked to visceral fat.Because sdLDL testing is specialised, the ApoB level and the LDL-C : ApoB ratio can be used to estimate particle size predominance:

Visceral Fat, Mitochondria, and the Energy Trap: Why We Store Fat Where We Shouldn’t

Visceral fat (VAT) is the dangerous, hidden fat stored around your organs that accumulates. when caloric intake exceeds energy demand, since glucose and fats that can’t be used gets stored as adipose tissue. This blog explains how ageing, muscle loss, glucose spikes and genetic factors all drive VAT accumulation — and how reversing the cycle requires restoring mitochondrial health, increasing muscle mass, and in many people, by reducing glycaemic overload.

Why “Pinchable Fat” May Not Be Harmless: Understanding Body Fat, Breathlessness, and Atrial Fibrillation

If have been told your weight is high but your blood tests are “fine”, or if you are living with breathlessness or atrial fibrillation, you may be wondering how your body fat is really affecting your heart and lungs.

Carbohydrate Sensitive Phenotype (CSP): Precursor of the Metabolic Syndrome?

Carbohydrate Sensitive Phenotype (CSP) is not a diagnosis of diabetes or obesity. Rather, it’s a biologically driven pattern of visceral fat accumulation and carbohydrate intolerance which is highly prevalent in those with a raised waist-to-height ratio (WHtR > 0.5), triggered by aging, Western-style diet and lifestyle. More importantly, CSP gives individuals a name for their experience—one that invites support instead of judgement, and allows them to engage with food and health choices free from social shame.

How to Mix GLP-1s, Hotels, Travel and Hospitality: A Modern Survival Guide

If you’re taking GLP-1 mimetics like Mounjaro, Ozempic, or Wegovy, you’re receiving a legitimate, medically prescribed therapy. Just like someone with asthma carries an inhaler, or a diabetic uses insulin, there’s no shame in needing a jab to support your metabolic health. Whether you are travelling or attending a hospitality event, here are some tips on how to navigate these new waters.

Can You Go Low-Carb with Kidney Disease? A Safer Way to Improve Blood Sugar Without Harming Your Kidneys

For patients with CKD 3b, a high-protein diet may accelerate renal decline and should be avoided. However, metabolic improvement via a moderate low-carbohydrate diet with controlled protein intake (~0.8 g/kg/day) and unsaturated fats is both feasible and safe when guided appropriately. Creatinine changes should be interpreted carefully in the context of diet, and dietary interventions should be closely monitored.

Why I Eat a Cooked Breakfast to Lower My Visceral Fat

When most people think of a cooked breakfast, they picture something indulgent — bacon, eggs, toast, maybe pancakes or juice. But my version of a cooked breakfast is carefully designed to help reduce visceral fat (VAT), improve satiety, and support stable energy levels throughout the morning. Here's how I do it — and why it works.